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Are your Nerves, Getting on your Nerves?

How CBD helps with Multiple Sclerosis & Peripheral Neuropathy  –

We have had many questions about these two things, and yes we know with that being said these two things are not the same thing!

Starting with Multiple Sclerosis, what is it? : Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects an estimated 2.3 million people worldwide (1).

Therefore symptoms to those with it are; pain, muscle spasticity, fatigue, inflammation, and depression. When you use CBD having MS, it acts as a natural anti-inflammatory, antioxidant, antiemetic, antipsychotic and neuroprotective. Helpings with heart rate, blood pressure & physical body temperature. Along with reduced fatigue, pain, spasticity, and ultimately improve mobility.

When visiting your doctor or physician, they will usually be ones to prescribe pharmaceutical opioids, benzodiazepines, and antidepressants. These though have the side effects of physical dependency, dizziness, sedation, nausea, vomiting, tolerance, constipation, and respiratory depression. If while taking these drugs and taking CBD, please be cautionary for it will make these medications more potent but also these side effects more prominent.

When taking benzodiazepines, these will affect sleep and staying asleep — also giving anterograde amnesia. As well as if you take this medication for an extended amount of time with getting drowsiness or also known as the “hangover effect.” If taking antidepressants to combat the other medication side effects, you will get nausea, fatigue, drowsiness. The anxiety may worsen and vision impairment and dizziness. Thus only causing more problems not fixing things, unlike CBD with no side effects.

What is Peripheral Neuropathy? 

As part of the central nervous system, the peripheral nervous system is made up of two components within the nervous system of humans. It is consisting of the nerves and ganglia outside of the brain and spinal cord.

To find out of you or someone else have PN, there must be a thorough examination of medical history and also be given a neurological exam.

Polyneuropathy– cause of peripheral nerve damage

There are many different causes of polyneuropathy, with some of the most common ones being:

  • Diabetes
  • Shingles
  • Alcohol abuse
  • Vitamin B12 deficiency
  • Hypothyroidism (an underactive thyroid gland)

Guillain Barre Syndrome:

One of the severe leading types of polyneuropathy. Characterizations of this would be progressive tingling and weakness, starting in the feet and rapidly growing up the legs. GBS can then affect the muscles that control breathing.

Mononeuropathy

It is a localized neuropathy, which is where only one nerve is damaged. Usually from trauma, compression, or entrapment. Which would be carpal tunnel syndrome, which refers to compression of the median nerve, causing numbness and tingling in the wrist.

Sensory

Receiving input from various locations of the body. Then to send messages to the brain about the body’s sensations, such as hot and cold, pain, and touch. If a sensory nerve is damaged, these would be the results.

  • Lack of sensation to pain changes in temperature
  • Unusual sensations like vibration, numbness, and tingling, burning, stabbing, electrical, or crawling
  • Pain from a light touch that is ordinarily painless (called allodynia)
  • Loss of position sense and balance problems
  • Change in temperature

Diabetic polyneuropathy is an example of predominantly sensory nerve damage (in this case, from high blood sugar levels). Symptoms usually begin in the toes and feet (on both sides of the body) and may include numbness, prickling, tingling, burning, and pain which become worse in the evening or while sleeping. If the disease progresses, it will then move up the legs, mid-calves, and even hand problems would begin to develop.

 

Motor nerves transmit messages from the brain and spinal cord, telling various muscles to move. When motor nerves are damaged, the most common symptom is muscle weakness.

Other symptoms and signs may include:

  • Muscle cramping and shrinking
  • Fasciculations (when a muscle twitches without your control)
  • Reflex abnormalities

Autonomic

By regulating how your internal organs, such as your blood vessels, stomach, heart, and sweat glands, function.

Common symptoms and signs of autonomic nerve damage include:

  • Excess sweating
  • Heat intolerance
  • Early satiety
  • Impotence
  • Orthostatic hypotension

Keep in mind, the symptoms of peripheral neuropathy can range in intensity from mildly bothersome to severe and disabling and develop gradually over the years, or in some cases, over days.

Diagnosis 

The diagnosis of peripheral neuropathy begins with a neurological examination.

Neurological Examination

Blood Tests

Nerve-Specific Tests

Autonomic Tests

and other test.

 

 

How CBD Can Help:

Starting with Multiple Sclerosis, CBD can help with the managing of symptoms as well as other neurodegenerative diseases. It also can modulate spasticity associated with MS, along with pain and bladder control. When taking CBD with medications for CBD, always check labeling for no THC, as well as the interferences with MS medications. High enough dosages, CBD will temporarily deactivate these liver enzymes, thereby altering how a wide range of compounds is metabolized. Therefore low dosing of CBD, can help benefit while consulting a doctor of coming off medications. 

 

If a person’s neuropathy is occurring as a result of diabetes, then obtaining better and tight control of glucose (sugar) levels may help preserve nerve function. Likewise, if a nutritional deficiency is the neuropathy culprit, then correcting it, should help the neuropathy. Therefore, CBD can help with maintaining correct blood sugar levels. As well as pain reduction, better sleep, and improved function, even in patients with symptoms refractory to standard therapies.

 

 

 

  1. Browne P, Chandraratna D, Angood C, Tremlett H, Baker C, Taylor BV, et al. Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology(2014) 83:1022–4.10.1212/WNL.0000000000000768

2. Rudroff, Thorsten, and Jacob Sosnoff. “Cannabidiol to Improve Mobility in People with Multiple Sclerosis.” Frontiers in Neurology, Frontiers Media S.A., 22 Mar. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5874292/.

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CBD & COPD

The American Lung Association Links COPD to be the third leading cause of death in the US.

What is COPD… Chronic Obstructive Pulmonary Disease is the progressing inflammation of lung disease that obstructs the air flow into the lungs — therefore making it hard to breathe.  COPD is also in association with the development of asthma, chronic bronchitis, pneumonia, and Emphysema.

When you have less of air flow in the airways, there is a lack of elasticity, and therefore more mucus is created thus causing clogging. Chronic bronchitis is what happens when the walls of the bronchial tubes because they think and inflamed, CBD helps with the reduction of inflammation. As to where in Emphysema, the walls which lay between the air sacs can be destroyed, therefore reducing airflow as well.

Causes of COPD are; cigarette smoke, second-hand smoke, air pollution, and exposure to dust and smoke. You can see the effects doing the following activities; walking, cooking, etc. simple task becomes more laborious.

Symptoms with COPD are; coughing large amounts of mucus, shortness of breath, wheezing and chest tightness. COPD usually found among middle-aged to older adults.

When having COPD, your risk for respiratory infections, heart problems, lung problems, lung cancer, high blood pressure, and depression are increased.

Findings: Effects of Cannabinoids and CBD on COPD

There can be a therapeutic beneficiary when using CBD, through many studies, CBD has been proven to help reduce inflammation and assisting in the inflamed airways to those with Chronic Bronchitis.

When CBD interacts with the CB1 & CB2 receptors, it is shown to reduce inflammation, among helping to create/maintain the homeostasis within the body. This activation of the receptors will help to reduce the airway inflammation. CBD also gives a potent anti-inflammatory agent in improving the lung function, even to a therapeutic level as a tool to treat many lung diseases.

Other research found is that cannabinoids found from cannabis can have amazing bronchodilators effects. Thus reducing the resistance in the respiratory airway and increasing airflow into the lungs. It can also be noted, that when CBD works with the CB1 receptor inhibits the contraction of the smooth muscle surrounding the lungs to dilate the bronchial tubes to open up more in the airways.

PLEASE NOTE: Smoking Cannabis can increase the acute and chronic bronchitis and irritate the lungs. It is especially heaving smoking, which can leave more obstruction. Instead, stick to other methods such as oils and edibles.

Recent Studies on Cannabinoids and CBD’s Effect on COPD

CBD has a potent anti-inflammatory effect and also improves lung function, suggesting it could be a useful therapeutic tool for the treatment of inflammatory lung diseases.
Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury.
(https://www.ncbi.nlm.nih.gov/pubmed/25356537)

Cannabis has shown to be useful for treating inflammation.
Cannabinoids, endocannabinoids, and related analogs in inflammation.
(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/)

References:

  1. Aldington, S., Williams, M., Nowitz, M., Weatherall, M., Pritchard, A., McNaughton, A., Robinson, G., and Beasley, R. (2007). Effects of cannabis on pulmonary structure, function and symptoms. Thorax, 62(12), 1058–1063. http://doi.org/10.1136/thx.2006.077081.
  2. Bento, A. F., Marcon, R., Dutra, R. C., Claudino, R. F., Cola, M., Pereira Leite, D. F., and Calixto, J. B. (2011). β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway. The American Journal of Pathology, 178(3), 1153–1166.
  3. Braun, A., Engel, T., Aguilar-Pimentel, J.A., Zimmer, A., Jakob, T., Behrendt, H, and Mempel, M. (2011, April). Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: role of CB1/CB2 receptors. Immunobiology, 216(4), 466-76.
  4. Burstein, S. H., and Zurier, R. B. (2009). Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation. The AAPS Journal, 11(1), 109.
  5. COPD. (2016, July 12). Mayo Clinic. Retrieved from http://www.mayoclinic.org/diseases-conditions/copd/home/ovc-20204882.
  6. Ferrini, M.E., Hong, S., Stierle, A., Stierle, D., Stella, N., Roberts, K., and Jaffar, Z. (2016, December 19). CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma. Allergy, doi: 10.1111/all.13107. [Epuc ahead of print]
  7. Grassin-Delyle, S., Naline, E., Buenestado, A., Faisy, C., Alvarez, J.C., Salvator, H., Abrial, C., Advenier, C., Zemoura, L., Devillier, P. (2014). Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors. British Journal of Pharmacology, 171(11), 2767–2777.
  8. Kozela, E., Pietr, M., Juknat, A., Rimmerman, N., Levy, R., and Vogel, Z. (2010). Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells. The Journal of Biological Chemistry, 285(3), 1616–1626.
  9. Ribeiro, A., Ferraz-de-Paula, V., Pinheiro, M.L., Vitoretti, L.B., Mariano-Souza, D.P, Quinteiro-Filho, W.M., Akamine, A.T., Almeida, V.I., Quevedo, J., Dal-Pizzol, F., Hallak, J.E., Zuardi, A.W., Crippa, J.A., and Palermo-Neto, J. (2012, March). Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor. European Journal of Pharmacology, 678(1-3), 78-85.
  10. Ribeiro, A., Almeida, V.I., Costola-de-Souza, C., Ferraz-de-Paula, V., Pinheiro, M.L., Vitoretti, L.B., Gimenes-Junior, J.A., Akamine, A.T., Crippa, J.A., Tavare-de-Lima, W., and Palermo-Neto, J. (2015, February). Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. Immunopharmacology and Immunotoxicology, 37(1), 35-41.
  11. Staiano, R.I., Loffredo, S., Borriello, F., Iannotti, F.A., Piscitelli, F., Orlando, P., Secondo, A., Granata, F., Lepore, M.T., Fiorelli, A., Varricchi, G., Santini, M., Triggiani, M., Di Marzo, V., and Marone, G. (2016, April). Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors. Journal of Leukocyte Biology, 99(4), 531-40.
  12. Tashkin, D.P., Shapiro, B.J., and Frank, I.M. (1974, April). Acute effects of smoked Cannabis and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects. The American Review of Respiratory Disease, 109(4), 420-8.
  13. Tashkin, D.P., Baldwin, G.C., Sarafian, T., Dubinett, S., and Roth, M.D. (2002, November). Respiratory and immunologic consequences of Cannabis smoking. Journal of Clinical Pharmacology, 42 (11 Suppl), 71S-81S.
  14. Turcotte, C., Blanchet, M.R., Laviolette, M., and Flamand, N. (2016, September 15). Impact of cannabis, cannabinoids, and endocannabinoids in the lungs. Frontiers in Pharmacology, 7, 317.
  15. What is COPD? (2014, May 22). National Heart, Lung, and Blood Institute. Retrieved fromhttps://www.nhlbi.nih.gov/health/health-topics/topics/copd.
  16. Yayan, J., and Rasche, K. (2016). Damaging Effects of Cannabis Use on the Lungs. Advances in Experimental Medicine and Biology, 952, 31-34.
  17. Yoshihara, S., Morimoto, H., Ohori, M., Yamada, Y., Abe, T., and Arisaka, O. (2005, May) The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues. Journal of Pharmacological Sciences, 98(1), 77-82.
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Introduction to CBD & What it could do!

06/07/2019

Pain Relief

ONE OF THE MOST CELEBRATED HEALTH BENEFITS OF CBD OIL IS THE ANALGESIC EFFECT. CBD INTERACTS WITH THE RECEPTORS IN THE BRAIN TO REDUCE INFLAMMATIONS THUS RELIEVING PAIN, WITHOUT INDUCING ADVERSE SIDE EFFECTS.

Diabetes

SEVERAL STUDIES SHOW THAT CANNABIS USERS HAVE A LOWER BMI, REDUCED RISK OF DIABETES, AND OBESITY. IN A 2015 AN ISRAELI-AMERICAN BIOPHARMACEUTICAL COLLECTIVE BEGAN STAGE 2 TRIALS RELATED TO USING CBD TO TREAT DIABETES RESEARCH DEMONSTRATED THAT CBD HELPS THE BODY CONVERT WHITE FAT INTO WEIGHT REDUCING BROWN FAT, PROMOTING NORMAL INSULIN PRODUCTION AND SUGAR METABOLISM.

Anxiety, Depression, PTSD & More

WHILE CBD IS COMMONLY USED TO ADDRESS PSYCHOLOGICAL SYMPTOMS, THERE IS A GROWING BODY OF RESEARCH THAT INDICATES THAT IT CAN ALSO BE USED IN THE THERAPY OF MENTAL HEALTH. RESULTS SUGGEST THAT CBD REDUCES THE ANXIETY, DEPRESSION, PTSD AND MORE, AND ITS EFFECTS ON THE LIMBIC & PARALIMBIC BRAIN AREAS.

NOTE : THOSE WITH THESE SYMPTOMS SHOULDN’T TAKE OILS WITH THC, OR THCA

EXERCISE INDUCED INFLAMMATION

EII DOESNT JUST IMPACT HOW YOUR BODY FEELS. ALSO YOUR ABILITY TO WORK AND FOCUS, HOW PRESENT YOU ARE IN YOUR RELATIONSHIPS, YOUR OVERALL FEELING IN LIFE, YOUR ABILITY TO GO BACK TO DOING YOUR FAVORITE ACTIVITES. FORTUNATELY, CBD CAN HELP. BY SUPPORTING MUSCLE REPAIR, REDUCING MUSCLE SORENESS, TAPERS MUSCLE STIFFNESS & MAXIMZING YOUR REST PERIODS.

READ MORE HERE; https://www.sagelynaturals.com/blogs/news/the-positive-effects-of-cbd-on-joint-pain

Cholesterol & Cardiovascular Disease

STUDIES HAVE SHOWN THAT CURRENT CBD USERS HAD HIGHER HDL (GOOD CHOLESTEROL) AND LOWER LDL (BAD CHOLESTEROL). WHEN LINKED TO DIET AND LIFESTYLE ATHEROSCLEROSIS (CLOGGED ARTERIES), AND CHRONIC INFLAMMATORY DISORDER INVOLVING THE PROGRESSIVE DEPOSITING OF PLAQUES (IMMUNE CELLS CARRYING OXIDIZED LDL), TRYING TO REPAIR DAMAGE TO THE ARTERY WALL. AS WELL AS ENDOCANNABINOID SIGNALING PLAYS A CRITICAL ROLL IN PATHOLOGY OF ATHEROGENESES. THIS CONDITION IS NOW UNDERSTOOD TO BE A PHYSICAL RESPONSE TO INJURIES DONE TO THE ARTERIAL WALL. CB2 RECEPTORS TRIPLE IN RESPONSE TO INFLAMMATION ALLWOING THE BODYS NATURAL CANNABINOIDS TO DECREASE INFLAMMATORY RESPONSE.

Anti Seizure Properties

SEIZURES OCCUR WHEN THERE IS A DRAMATIC FLUCTUATION OF ELECTRICAL ACTIVITY IN THE BRAIN. CBD HAS BEEN THOUGHT TO CALM THIS ACTIVITY. ITS ONLY RECENTLY THAT STUDIES HAVE BEEN ABLE TO CONFIRM THIS.

THE NEW ENGLAND JOURNAL OF MEDICINE SHOWED A 38.9% REDUCTION IN SEIZURE ACTIVITY

Cancer

CBD AS WELL AS OTHER COMPOUNDS IN HEMP COULD HAVE ANTITUMOR EFFECT AND AMPLIFY THE DEATH OF TUMOR CELLS. THESE STUDIES ARE PROMISING, WHEN PAIRED WITH PAIN RELIE REDUCTIONS OF ANXIETY. CBD COULD ADDRESS SEVERAL NEEDS THAT ARISE WHILE DEALING WITH A CANCER DIAGNOSIS.